-Amyloid Modulation of Synaptic Transmission and Plasticity

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چکیده

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-Amyloid Modulation of Synaptic Transmission and Plasticity

Deepa V. Venkitaramani,1 Jeannie Chin,2 William J. Netzer,3 Gunnar K. Gouras,4 Sylvain Lesne,5 Roberto Malinow,6 and Paul J. Lombroso1 1Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520, 2Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, California 94158, 3Laboratory of Molecular and Cellular Neuroscience, and...

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The effect of ketamine (1-100 µM), which has NMDA receptor antagonist properties, on synaptic transmission and long-term potentiation (LTP) in CAl area of rat hippocampus was examined in vitro. Field potentials were recorded in pyramidal cell layer following Schaffer collateral stimulation. Primed-burst stimulation (PEs) was used for induction of LTP. The amplitude of population spiks (PS) was ...

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ژورنال

عنوان ژورنال: Journal of Neuroscience

سال: 2007

ISSN: 0270-6474,1529-2401

DOI: 10.1523/jneurosci.3478-07.2007